Table 3.

Weight and Clinical Laboratory Test Results: Baseline Values and Changes From Baseline at Week 12

LisinoprilHCTZPlacebo
TestBaselineΔBaselineBaselineΔBaselineBaselineΔBaseline
Weight, kg96.9 (14.7)−0.4 (15.5)96.9 (16.4)−0.4 (16.6)98.2 (16.8)−0.2 (17.0)
Glucose, mmol/L5.70 (0.83)−0.21 (0.71)5.81 (0.94)+0.31 (0.99)15.78 (1.01)−0.16 (0.90)
Insulin, pmol/L76.2 (48.0)12.6 (78.6)108.6 (121.2)13.2 (130.8)133.2 (210.6)−33.0 (210)
Insulin-glucose ratio10.81 (10.81)0 (10.81)21.62 (21.62)0 (21.62)21.62 (32.43)0 (32.43)
Total cholesterol, mmol/L5.09 (0.95)0.06 (0.50)5.17 (1.23)−0.14 (0.97)5.27 (1.06)−0.04 (0.57)
HDL cholesterol, mmol/L0.92 (0.29)−0.02 (0.26)0.90 (0.31)0.01 (0.21)0.87 (0.34)0.07 (0.26)
LDL cholesterol, mmol/L3.27 (0.72)0.06 (0.59)3.15 (0.95)0.10 (0.52)3.44 (0.84)−0.10 (0.57)
VLDL cholesterol, mmol/L0.54 (0.39)0.04 (0.26)0.65 (0.81)0.02 (0.69)0.52 (0.38)0.03 (0.29)
Triglyceride, mmol/L1.72 (0.89)0.08 (0.51)1.93 (1.65)−0.04 (1.32)1.73 (0.86)0.01 (0.56)
VLDL triglyceride, mmol/L1.12 (0.78)0.08 (0.52)1.31 (1.42)0.01 (1.16)1.13 (0.79)−0.01 (0.59)
Potassium, mmol/L4.3 (0.4)0.1 (0.2)4.3 (0.3)−0.4 (0.1)24.3 (0.3)0.04 (0.1)
  • HDL indicates high-density lipoprotein; LDL, low-density lipoprotein; and VLDL, very-low-density lipoprotein. Values in parentheses are SD.

  • 1 P<.001,

  • 2 P<.0001 lisinopril vs HCTZ.