Table 5.

Sibling Analysis

Risk FactorsNo. of ObservationsMean Differences (95% CI) Between Siblings Exposed to Maternal Hypertensive Disorder of Pregnancy and Their Siblings Born After Normotensive Pregnancy
Systolic blood pressure, mm Hg470−0.7 (−3.0 to 1.5)
Diastolic blood pressure, mm Hg470−0.8 (−2.6 to 0.9)
Body mass index, kg/m24700.01 (−0.74 to 0.75)
Waist circumference, cm463−0.09 (−2.09 to 1.91)
Waist–hip ratio463−0.001 (−0.013 to 0.010)
HDL cholesterol, mmol/L459−0.02 (−0.07 to 0.04)
Non-HDL cholesterol, mmol/L4590.11 (−0.07 to 0.29)
Triglycerides, mmol/L461−0.01 (−0.13 to 0.13)
C-reactive protein, mg/L267−0.10 (−0.41 to 0.34)
  • Mean differences in cardiovascular risk factors in adult offspring exposed to maternal hypertensive disorder compared with their unexposed siblings, adjusted for age, sex, maternal parity, and HUNT (Nord-Trøndelag Health Study) survey. The analysis includes 210 sibling groups where at least one sibling was born after hypertensive pregnancy and at least one sibling was born after normotensive pregnancy (total n=472). CI indicates confidence interval; and HDL, high-density lipoprotein.